SERMORELIN

WHAT IS SERMORELIN

Sermorelin is a synthetically made version of growth hormone releasing hormone (GHRH), the endogenous hormone responsible for stimulating natural growth hormone production. Sermorelin is a growth hormone(GH) secretagogue that stimulates increased production of GH from the anterior pituitary gland.

Like the body’s natural GHRH, Sermorelin works by binding to the growth hormone releasing hormone receptor (GHRH) in the anterior part of the pituitary gland. Sermorelin functions to stimulate greater production of GH, leading to an increase in production of your own produced IGF-1 . Sermorelin acts as a mirror image to GHRH and causes the same effect on GH production. The effect of Sermorelin is regulated by a negative feedback mechanism known as Somatostatin. This has a couple of positive effects in the body including the prevention of maximum, unhealthy GH levels in the body, and the mirroring of more natural fluctuating pulsing in GH concentrations.

Sermorelin’s natural action mechanism allows for the preservation of the hypothalamic-pituitary-somatotropic axis, preventing the shutdown of hormone production that typically accompanies direct replacement with HGH. Further, Sermorelin has also been shown to improve sleep quality, enhancing the duration of restorative slow wave sleep and amplifying sleep-related secretion of growth hormone while reducing production of cortisol (a catabolic stress hormone).

BENEFITS OF SERMORELIN

Sermorelin stimulates improved natural growth hormone production, resulting:

• increased muscle

• increased lean body mass

• decreased body fat

• enhanced recovery from injuries and training session

• deeper, more restful sleep

• enhanced flexibility and joint inflammation.

• improved immune health.

Enhanced growth hormone (GH) levels also stimulate greater production of Insulin-like Growth Factor 1 (IGF-1) in the body, further driving improvements in lean body composition with accelerated growth of muscle tissue and reduced body fat. Importantly, as Sermorelin stimulates the body’s natural growth hormone output, and helps to remove the negative side effects often associated with synthetic HGH. These can include shutdown of natural growth hormone production, acromegaly, and carpal tunnel syndrome.

Suboptimal levels of growth hormone in the body can devastate an individual’s athletic ability, functional capacity, and overall health. With low growth hormone levels one may notice loss in normal full sleep, weak bones, loss of muscle mass, increased body fat, and poor healing. Unfortunately, age related declined related to decreasing growth hormone leads to many debilitating effects as we age.

To increase growth hormone levels, Sermorelin stimulates the pituitary gland to produce greater amounts of natural GH. Critically, Sermorelin stimulates natural, endogenous production and is not simply a synthetic HGH, a fact which offers several important advantages. First, overdoses are virtually impossible, as its effects are mediated with negative feedback by the body’s own regulatory mechanisms. As a result, GH production is unable to reach dangerously high levels, and many of the previously mentioned negative side effects of synthetic HGH administration are avoided. Second, the body’s own production of growth hormone is enhanced rather than shut down (as occurs with administration of exogenous HGH). Therefore, there is no risk of a hormonal crash upon cessation of Sermorelin administration. Third, there is also no likelihood of a diminishing response to administration as there is with HGH. This is due to Sermorelin promotion of enhanced yet natural levels of growth hormone in the body. In maintaining blood levels that more closely resemble the body’s own growth hormone pattern, Sermorelin remains consistently effective at a given dose.

WHAT ARE THE SIDE EFFECTS OF SERMORELIN

Side effects of Sermorelin are generally mild and may include flushing, dizziness, headache, or pain at injection site immediately after administration. These typically are fleeting and may lessen considerably with continued treatment. A more common side effect is sleepiness due to its impact on GH and cortisol levels as well as slow wave sleep. This is why we recommend treating at night along w/ the added benefit of the body’s own natural production time for growth hormone. Sermorelin may interact with glucocorticoid medication, so those who require it would be wise to consult their doctor prior to use.

Body Protection Compound (BPC) 157, is a fragment of a protein found in gastric juice. Its tissue-regenerative ability isn’t limited to the GI tract and has also been found to have profound healing and repair effects in nearly every tissue that has been studied.

BPC-157 is a synthetic version of a compound found naturally in the stomach that is thought to be a healing protein. Some studies have shown accelerated healing in animals and shorter recovery time. Other studies have noted potential benefits of improved movement, strength, and flexibility.

BPC-157 may benefit brain function as well as accelerated wound recovery. There have been some studies to show significant improvement for connective tissues such as ligaments and tendons, but more research is needed.

POTENTIAL BENEFITS OF USING BPC 157

Outside of musculoskeletal repair, recovery from exercise, and body stress, there are potentials for neurologic disorders, GI inflammatory bowel disease, GERD, among other inflammation improvement. Chronic use of drugs like systemic steroids and NSAIDS have numerous side effects and BPC-157 may be a substitute for treatment.

BPC 157 is often found to benefit three major areas: Gut Health, Joint Health, and Wound Healing. Potential benefits as below:

• Accelerated healing from injury and training

• Rapid tendon and ligament healing

• Enhanced joint mobility

• Stronger connective tissue

• Improved flexibility

• Protection against injury

• Wound healing: induces faster muscle and wound healing and also accelerates cell outgrowth.

• Joint health: reverses systemic corticosteroid-impaired muscle healing

• Gut health

HOW DOES BPC 157 WORK

Currently, it is known that BPC-157 circulates through the entire body and is attracted to signaling molecules produced by injured tissues, but it is still unknown for certainty the exact mechanism with which it heals. At present it is speculated that it most likely varies depending on the particular tissue and nature and mechanism of the injury.

Although the way in which BPC-157 works is not fully understood, the scientific literature has identified some potential sources of this compound’s healing power. A link is noted between BPC-157 and its effect on the FAK-paxillin pathway (focal adhesion kinase – an enzyme present in injured tissues), nitric oxide, increased VEGF activity (vascular endothelial growth factor), and the upregulation of growth hormone receptors in injured tissues.

VEGF specifically is responsible for angiogenesis of new blood vessels and is the most likely mechanism by which BPC-157 is able to promote the healing of joint structures, tendons, and ligaments as it allows for an increased delivery of nutrients and various healing factors that are required for growth and repair.

WHAT ARE SOME PRECAUTIONS OF BPC-157

BPC-157 has a unique status somewhere between a supplement and a pharmaceutical drug. It has not been extensively studied in humans. However, in the human trials that have been done as well as in the clinical application that has already taken place, there have been essentially no reported adverse events. Those that have had any side effects are typically digestive in nature and often mild nausea. To get the most benefit from administration of BPC-157 it should be combined with nutrition and lifestyle modifications.

BENEFITS OF IPAMORELIN

•Very strong anti-aging benefits

•May increase athletic performance, endurance, and recovery

•Increased muscle mass

•Enhanced joint health and flexibility

•Decreased body fat

•Promotes better recovery from injuries and training sessions

•More full, restful sleep

•Improved overall health and wellness

Ipamorelin also increases production of Insulin-like Growth Factor 1 (IGF-1) in the body. This increases the benefits of improved recovery, strength, and lean body mass by speeding up tissue repair and associated muscle growth. In addition, Ipamorelin’s method of action prevents many of the negative side effects of synthetic hGH administration, including the shutdown of natural growth hormone production.

Ipamorelin is regarded as one of the mildest growth hormone releasing peptides in terms of negative side effects. Even with long term use, concerns of adverse effects are rarely reported. Additionally, it has a negligible effect on cortisol, prolactin, and appetite, unlike other GHRPs. As a result of its targeted effects on natural growth hormone production and its well-tolerated profile, Ipamorelin is one of the most widely sought-after anti-aging peptides.

SERMORELIN

WHAT IS SERMORELIN

Sermorelin is a synthetically made version of growth hormone releasing hormone (GHRH), the endogenous hormone responsible for stimulating natural growth hormone production. Sermorelin is a growth hormone(GH) secretagogue that stimulates increased production of GH from the anterior pituitary gland.

Like the body’s natural GHRH, Sermorelin works by binding to the growth hormone releasing hormone receptor (GHRH) in the anterior part of the pituitary gland. Sermorelin functions to to stimulate greater production of GH, leading to an increase in production of your own produced IGF-1 . Sermorelin acts in as a mirror image to GHRH and causes the same effect on GH production. Sermorelin effect is regulated by negative feedback mechanism by Somatostatin also known as growth hormone inhibiting hormone(GHIH).As it exerts its effects in an identical manner to GHRH, Sermorelin positive effect on GH output is modulated by a negative feedback mechanism initiated by somatostatin, the endogenous hormone also known as growth hormone inhibiting hormone(GHIH).This has several positive effects, two of which are the prevention of maximum, unhealthy GH levels in the body and the mirroring of more natural fluctuating pulsing in GH concentrations.

Sermorelin natural action preserves this feedback mechanism while at the same time decreasing its overall strength. It’s natural action mechanism allows for the preservation of the hypothalamic-pituitary-somatotropic axis, preventing the shutdown of hormone production that typically accompanies direct replacement with HGH. Further, Sermorelin has also been shown to improve sleep quality, enhancing the duration of restorative slow wave sleep and amplifying sleep-related secretion of growth hormone while reducing production of cortisol (a catabolic stress hormone).

WHAT ARE THE POTENTIAL BENEFITS OF SERMORELIN/IPAMORELIN

•Decreased visceral body fat

•Decreased waistline size

•Faster weight loss

•Increased lean muscle

•Improved athletic prowess

•Improved muscle recovery after workout

•Increased libido

•Sound sleep

•Stronger immune system

•Increased cell repair & regeneration

•Increased collagen production

WHAT ARE THE SIDE EFFECTS OF SERMORELIN AND IPAMORELIN

Ipamorelin is one of the most well-tolerated growth hormone secretagogue. Any side effects that may occur are typically mild and dose-dependent, with negative effects rarely occurring at moderate dosage levels.

Most common side effects of Sermorelin and Ipamorelin:

•Mild flushing

•Headache may occur upon initial administration, though this commonly goes away after repeated injections

•Temporary nausea and upset stomach may additionally occur following administration.

•Feelings of tiredness or fatigue is possible, as growth hormone can increase the desire for sleep as well as its quality and restorative capabilities. We recommend dosing before sleep. This is also beneficial to your natural timing of growth hormone secretion.

• Ipamorelin does not elevate adrenocorticotropic hormone (ACTH), cortisol, and prolactin when used as recommended. When used at extremely high dosages, however, it can have a stimulatory effect on these hormones. Though not an issue for the vast majority of users, this may cause interactions with certain medications or unwanted effects in individuals with certain health conditions. Excessive dosages of Ipamorelin may also lead to water retention as well as tingling or numbness in the hands and feet. This can be another sign that the dosage is too high and should be reduced.

•Side effects of Sermorelin are similar and also include pain at the injection site which is generally mild. Sermorelin may interact with glucocorticoid medication, so those who require it would be wise to consult their doctor prior to use.

CJC-1295 is an incredibly effective growth hormone. It stimulates the release of your own body’s growth hormone naturally by binding to receptors for growth hormone releasing hormone (GHRH) on your brain, and more specifically the pituitary gland. This action triggers the brain to release growth hormone that would have otherwise been lost with age.

Research completed with healthy men and women between the ages of 21 and 61, showed that CJC-1295 had the ability to increase serum growth hormone levels by 200-1000%. In these individuals, the elevated growth hormone production and release continued for up to 6 days because CJC-1295 has a half-life of approximately 6-8 days. This longer half-life means the body continues to produce more growth hormone beyond the initial injection compared to other peptides that also have similar actions. For this reason and a few more, CJC-1295 has become very effective peptide for safely increasing growth hormone levels.

CJC-1295 has as demonstrable safety record and increases growth hormone levels safely due to causing the body to natural produce more growth hormone vs the side effects that can be noted with exogenous HGH treatment.

WHAT ARE THE BENEFITS OF CJC-1295

Benefits may include:

•Promoting deep sleep

•Optimizing athletic performance

•Building lean muscle

•Reducing fat

•Increasing GH and IGF-1 levels

WHAT ARE COMMON SIDE EFFECTS OF CJC-1295

•Most common, local site injection inflammation.

•Flu-like symptoms

•Headache

•Irritability

•Anxiety

•Nausea

•Itching and Hives

WHAT IS IPAMORELIN

Ipamorelin acts in a completely different way to stimulate growth hormone release. Ipamorelin helps to release growth hormone because it mimics ghrelin. Ghrelin is one of three hormones which together act to regulate growth hormone release from the pituitary gland. This is an important distinction between both peptides, because Ghrelin also works at the pituitary gland and is responsible for initiating the breakdown of fat for use as energy as well as preventing the breakdown of muscles.

Ipamorelin also increases production of Insulin-like Growth Factor 1 (IGF-1) in the body. This increases the benefits of improved recovery, strength, and lean body mass by speeding up tissue repair and associated muscle growth. In addition, Ipamorelin’s method of action prevents many of the negative side effects of synthetic HGH administration, including the shutdown of natural growth hormone production.

BENEFITS OF IPAMORELIN

•Very strong anti-aging benefits

•May increase athletic performance, endurance, and recovery

•Increased muscle mass

•Enhanced joint health and flexibility

•Decreased body fat

•Promotes better recovery from injuries and training sessions

•More full, restful sleep

•Improved overall health and wellness

Ipamorelin is regarded as one of the mildest growth hormone releasing peptides in terms of negative side effects. Even with long term use, concerns of adverse effects are rarely reported. Additionally, it has a negligible effect on cortisol, prolactin, and appetite, unlike other GHRPs. As a result of its targeted effects on natural growth hormone production and its well-tolerated profile, Ipamorelin is one of the most widely sought-after anti-aging peptides.

WHY COMBINE CJC-1295 AND IPAMORELIN

CJC-1295 and Ipamorelin are typically combined in therapy because they are known to work well together. CJC-1295 takes anywhere from 1-4 hours to reach peak serum in the blood, while Ipamorelin works much quicker. Ipamorelin is cleared from the body more rapidly as its half-life is about 2 hours. The combination of both peptides ensures a rapid onset with Ipamorelin and lasting effects with CJC-1295. These 2 peptides are incredibly specific at increasing growth hormone levels when compared to other peptides. Other peptide can increase levels of cortisol (as seen with stress, can increase hunger) but neither Ipamorelin nor CJC-1295 have an effect on other hormones which is a great advantage.

WHAT ARE THE SIDE EFFECTS CJC-1295 / IPAMORELIN

When taken in low to moderate doses, mild side effects may include:

•Redness, flushing and or itching after the injection that resolves in a few minutes

•Dry mouth

•Nausea

•Weight gain usually associated with increased muscle mass

Although less common, Ipamorelin may cause in high doses:

•Water retention

•Tingling or numbness of the hands and feet

•Insulin resistance

•Hypertension

There may be additional side effects if taken with other supplements that work on the same pathway as Ipamorelin.

What is GHK-CU?

GHK-CU is a human peptide(glycyl-l-histidyl-l-lysine) that has multiple modes of actions that have been found to stimulate blood vessel and nerve outgrowth, increase collagen production, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts which are found to allow skin to recover from injury and also generate connective tissue.

GHK-CU, a human copper binding peptide, is a small, naturally occurring tri-peptide present in human plasma that also can be released from tissues if an injury occurs. GHK-CU was first discovered in 1973 and has been found to be a powerful protective and regenerative agent that is currently used primarily for skin and hair health.

GHK-CU demonstrated improve tissue repair for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK-CU has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, DNA repair, and anti-aggression activities.

WHAT ARE THE BENEFITS OF GHK-CU

•Tighten loose skin and reverse thinning of aged skin

•Repair protective skin barrier proteins

•Promote wound healing

•Improve skin firmness, elasticity, and brightness.

•Reduce fine lines, depth of wrinkles, and improve structure of aged skin

•Soothes rough skin

•Reduce photodamage, mottled hyperpigmentation, skin spots and lesions

•Improve overall skin appearance

•Stimulate wound healing

•Protect skin cells from UV radiation

•Reduce inflammation and free radical damage

•Increase hair growth and thickness, enlarge hair follicle size

HOW DOES GHK-CU WORK

GHK-CU works primarily because of its ability to bind copper ions. GHK-CU has also been found to have the ability to up- and down-regulate a significant number of human genes.

The biological effects of GHK-CU such had wound healing and skin repair are well known and and its effects on gene actions continue to be further investigated for its positive effects.

For skin, GHK-CU activates collagen to build up tissue, increase certain enzymes that replenish the skin by removing old cells and increase the matrix of skin to give it a thicker, younger, youthful appearance.

GHK-CU also speeds up wound healing, formation of granular tissue, as well as increasing activity of antioxidant enzymes and stimulating blood vessel growth. Dressings soaked (impregnated) with GHK-CU increased wound healing 10 fold.

Nerve growth with GHK -CU appears to help restore the skin’s innervation through increased production of neurotrophic factors - especially after an injury when the scar area is devoid of feeling.

GHK-CU also appears to support remodeling and restructuring of connective tissue, modulating expression of numerous genes, including up-regulation of genes of the TGF-β pathway. This pathway is necessary for of lung tissue in patients with COPD.

GHK -CU has potent anti-pain, anti-anxiety (anxiolytic) and anti-aggression actions. Research shows topical applications may help with pain both from a sensory perspective and also an anti-inflammatory sense.

GHK-CU Side Effects:

GHK-CU has little to no side effects. Most important conditions that accumulate copper should not use this product or known allergy to Copper. Avoid treatment if pregnant or breast-feeding. Do not combine with Vitamin C, L-Ascorbic, and alpha hydroxy acids as this can reduce the effect of GHK-CU peptide therapy.

Most common side effect is:

•Injection site reactions (such as pain, swelling, or redness)

•Skin irritation, mostly seen with sensitive skin

•Nausea, headache, fatigue, and dizziness. Possible low blood pressure changes.

GHK-CU can be used with BPC 157